Multi- “Multimodality” Imaging of Microwave Ablation Therapy Efficacy with microPET/CT/MRI/Optical

Christophsen, M. et al.
University of Wisconsin-Madison, Madison, Wisconsin, USA
 |  2010-02-03


Microwave (MW) ablation is the most recent version of ablative minimally invasive therapy for cancer treatment, and missed tumor margin is its biggest pitfall. NM404 is a second-generation phospholipid ether analogue that has shown tumor avidity in several models and is currently in Phase I clinical trials for lung and breast. The purpose of this experiment was to qualitatively and quantitatively assess the efficacy of microwave ablation (MW) therapy with NM404 utilizing microPET/CT/MRI and optical modalities.